Publications.

Publications by Aiman Saab and our collaborators, curated by the lab. See Aiman's ORCID record.

2026

Red Fluorescent Labeling of Myelin by Membrane‐Targeted tdTomato in Transgenic Mouse Lines

Anja Reinert, Ulrike Winkler, Sandra Goebbels, Lina Komarek, Wiebke Möbius, Henri Seraf Zanker, Karl Schoknecht, Grit Bornschein, Hartmut Schmidt, Robert Fledrich, Ruth M. Stassart, Petra G. Hirrlinger, Klaus‐Armin Nave, Hauke B. Werner, Aiman S. Saab, Johannes Hirrlinger

Glia

PMID 42875964, DOI

A longitudinal two-photon imaging platform for focal astrocyte ablation in vivo

Nicola B. Schmid, Matthias T. Wyss, Anna Lasne, Ria Patoli, Jeffrey L. Bennett, Aiman S. Saab, Bruno Weber, Marina Herwerth

bioRxiv (preprint)

DOI

Focal astrocyte loss reveals nuclear translocation during lesion repopulation

Marina Herwerth, Matthias T. Wyss, Nicola B. Schmid, Anna Lasne, Jacqueline Condrau, Luca Ravotto, José María Mateos Melero, Andres Kaech, Gustav Bredell, Carolina Thomas, Rachel Kim, Petra Kukanja, Vladyslav L. Korobeynyk, Christine Stadelmann, Thomas Misgeld, Jeffrey L. Bennett, Sebastian Jessberger, Aiman S. Saab, Shane A. Liddelow, Bruno Weber

Nature Neuroscience

PMID 42493549, DOI

Astroglial disinhibition of cortical circuits disrupts cognition via kynurenic acid in mice

Viktor Beilmann, Johanna Furrer, Sina M. Schalbetter, Ron Schaer, Edoardo Tiziani, Kim D. Ferrari, Felisa Herrero, Celine Heeb, Alexandra von Faber-Castell, Jacqueline Condrau, Ulrike Weber-Stadlbauer, Matthias T. Wyss, Aiman S. Saab, Sarah Beggiato, Urs Meyer, Bruno Weber, Tina Notter

Nature Communications

PMID 42098131, DOI

Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species

Juan Villar-Vesga, Donatella De Feo, Pauline Clément, Viola Bugada, Elèni Meuffels, Hannah Van Hove, Mitchell Bijnen, James King, Sophie Grundschober, Can Ulutekin, Maria Pena-Francesch, Sara Costa-Pereira, Laura Oberbichler, Violetta S. Gogoleva, Jeanne Kim, Katarina Wendy Schmidt, Musadiq Ahmad Bhat, Deborah Greis, Frauke Seehusen, Francesco Prisco, Urvashi Dalvi, Dietmar Benke, Bettina Schreiner, Tommaso Patriarchi, Florian Ingelfinger, Isabelle Catherine Arnold, Christian Münz, Melanie Greter, Aiman S. Saab, Burkhard Becher, Sarah Mundt

Science Immunology

PMID 42102230, DOI

Intrinsic endothelial remodeling drives brain capillary repair

Jacqueline Condrau, Chaim Glück, Matthias T. Wyss, Ladina Hösli, Eva Erlebach, Henri S. Zanker, Alexandra von Faber-Castell, Luca Ravotto, Gina Eberle, Srinivasa R. Allu, Tatiana V. Esipova, Thomas Troxler, Jeffrey L. Bennett, Marina Herwerth, Susanne Wegener, Aiman S. Saab, Sergei A. Vinogradov, Mohamad El Amki, Bruno Weber

Neuron

PMID 42119560, DOI

Astrocytes connect specific brain regions through plastic networks

Melissa Cooper, María Clara Sellés, Michael Cammer, Chase Redd, Holly K. Gildea, Joseph Sall, Katelyn E Chiurri, Philip Cheung, Damian G. Wheeler, Aiman S. Saab, Shane A. Liddelow, Moses V. Chao

Nature

PMID 42020738, DOI

2025

Scale-spanning crosstalk between metabolism and information processing

L. Felipe Barros, Ignacio Fernández‐Moncada, Giovanni Marsicano, Iván Ruminot, Aiman S. Saab, Bruno Weber

Cell Metabolism

PMID 41253157, DOI

Abundance-biased codon diversification prevents recombination in AAV production and ensures robust in vivo expression of functional FRET sensors

Jan Dernič, Afroditi Eleftheriou, Lazaros Vasilikos, Melanie Rauch, Pascal Imseng, Henri S. Zanker, Zoe J. Looser, R. Meister, Felipe Velasquez Moros, Tomer Kagan, Tal Laviv, Jean‐Charles Paterna, Michael Arand, Aiman S. Saab, Bruno Weber, Luca Ravotto

Communications Biology

PMID 40830588, DOI

Embracing the Modern Biochemistry of Brain Metabolism

Juan P. Bolaños, Cristina M. Alberini, Ángeles Almeida, L. Felipe Barros, Gilles Bonvento, Anne‐Karine Bouzier‐Sore, Ralf Dringen, Giles E. Hardingham, Johannes Hirrlinger, Pierre J. Magistretti, Giovanni Marsicano, Klaus‐Armin Nave, Rosa Chiara Paolicelli, Luc Pellerin, Pierre-Yves Plaçais, Thomas Préat, Nathalie Rouach, Iván Ruminot, Aiman S. Saab, Carmen Sandi, Stefanie Schirmeier, Avital Schurr, Jimena Sierralta, Maite Solas, Vanja Tepavčević, Bruno Weber, Eduardo R. Zimmer

Journal of Neurochemistry

PMID 40686252, DOI

Astrocytic GLUT1 deletion in adult mice enhances glucose metabolism and resilience to stroke

Laetitia Thieren, Henri S. Zanker, Jeanne Droux, Urvashi Dalvi, Matthias T. Wyss, Rebecca Waag, Pierre‐Luc Germain, Lukas von Ziegler, Zoe J. Looser, Ladina Hösli, Luca Ravotto, E. Dale Abel, Johannes Bohacek, Susanne Wegener, L. Felipe Barros, Mohamad El Amki, Bruno Weber, Aiman S. Saab

Nature Communications

PMID 40328784, DOI

A low-cost FPGA-based approach for pile-up corrected high-speed in vivo FLIM imaging

Felipe Velasquez Moros, Dorian Amiet, R. Meister, Alexandra von Faber-Castell, Matthias T. Wyss, Aiman S. Saab, Paul Zbinden, Bruno Weber, Luca Ravotto

Neurophotonics

PMID 40331236, DOI

2024

Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

Ebrahim Asadollahi, Andrea Trevisiol, Aiman S. Saab, Zoe J. Looser, Payam Dibaj, Reyhane Ebrahimi, Kathrin Kusch, Torben Ruhwedel, Wiebke Möbius, Olaf Jahn, Jun Yup Lee, Anthony S. Don, Michelle‐Amirah Khalil, Karsten Hiller, Myriam Baes, Bruno Weber, E. Dale Abel, Andrea Ballabio, Brian Popko, Celia M. Kassmann, Hannelore Ehrenreich, Johannes Hirrlinger, Klaus‐Armin Nave

Nature Neuroscience

PMID 39251890, DOI

A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome

Karan Ahuja, Marjan Vandenabeele, Fatemeharefeh Nami, Evy Lefevere, J. Van hoecke, Steven Bergmans, Marie Claes, Tim Vervliet, Katrien Neyrinck, Timothy C. Burg, D. De Herdt, P. Bhaskar, Yongwei Zhu, Zoe J. Looser, Jens Loncke, Willy Gsell, Mario Plaas, Patrizia Agostinis, Johannes V. Swinnen, Ludo Van Den Bosch, Geert Bultynck, Aiman S. Saab, Esther Wolfs, Yoke Chin Chai, Uwe Himmelreich, Catherine M. Verfaillie, Lieve Moons, Lies De Groef

Acta Neuropathologica Communications

PMID 39198924, DOI

Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health

Zoe J. Looser, Zainab Faik, Luca Ravotto, Henri S. Zanker, Ramona B. Jung, Hauke Werner, Torben Ruhwedel, Wiebke Möbius, Dwight E. Bergles, L. Felipe Barros, Klaus‐Armin Nave, Bruno Weber, Aiman S. Saab

Nature Neuroscience

PMID 38267524, DOI

2023

Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation

Vyara Todorova, Mia Fee Stauffacher, Luca Ravotto, Sarah Nötzli, Duygu Karademir, Lynn J. A. Ebner, Cornelia Imsand, Luca Merolla, Stefanie M. Hauck, Marijana Samardzija, Aiman S. Saab, L. Felipe Barros, Bruno Weber, Christian Grimm

Molecular Neurodegeneration

PMID 36882871, DOI

2022

Direct vascular contact is a hallmark of cerebral astrocytes

Ladina Hösli, Marc Zuend, Gustav Bredell, Henri S. Zanker, Carlos Oliveira, Aiman S. Saab, Bruno Weber

Cell Reports

PMID 35385728, DOI

Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

Ladina Hösli, Noemi Binini, Kim David Ferrari, Laetitia Thieren, Zoe J. Looser, Marc Zuend, Henri S. Zanker, Stewart Berry, Martin Holub, Wiebke Möbius, Torben Ruhwedel, Klaus‐Armin Nave, Christian Giaume, Bruno Weber, Aiman S. Saab

Cell Reports

PMID 35263595, DOI

2021

Distinct signatures of calcium activity in brain mural cells

Chaim Glück, Kim David Ferrari, Noemi Binini, Annika Keller, Aiman S. Saab, Jillian L. Stobart, Bruno Weber

eLife

PMID 34227466, DOI

Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans

Fabian S. Passini, Patrick K. Jaeger, Aiman S. Saab, Shawn L. Hanlon, Nicole Angela Chittim, Matthias Arlt, Kim David Ferrari, Dominik Haenni, Sebastiano Caprara, Maja Bollhalder, Barbara Niederöst, Aron N. Horvath, Tobias Götschi, Shang Ma, Bettina Passini-Tall, Sandro F. Fucentese, Ulrich Blache, Unai Silván, Bruno Weber, Karin Grävare Silbernagel, Jess G. Snedeker

Nature Biomedical Engineering

PMID 34031557, DOI

2020

Arousal-induced cortical activity triggers lactate release from astrocytes

Marc Zuend, Aiman S. Saab, Matthias T. Wyss, Kim David Ferrari, Ladina Hösli, Zoe J. Looser, Jillian L. Stobart, Jordi Durán, Joan J. Guinovart, L. Felipe Barros, Bruno Weber

Nature Metabolism

PMID 32694692, DOI

2019

Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation

Jennifer Romanos, Dietmar Benke, Aiman S. Saab, Hanns Ulrich Zeilhofer, Mirko Santello

Communications Biology

PMID 30963115, DOI

2018

Non-Canonical Control of Neuronal Energy Status by the Na+ Pump

Felipe Baeza‐Lehnert, Aiman S. Saab, Robin Gutiérrez, Valeria Larenas, Esteban F. Díaz, Melanie Horn, Miriam Vargas, Ladina Hösli, Jillian L. Stobart, Johannes Hirrlinger, Bruno Weber, L. Felipe Barros

Cell Metabolism

PMID 30527744, DOI

Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons

Zoe J. Looser, Matthew Barrett, Johannes Hirrlinger, Bruno Weber, Aiman S. Saab

Frontiers in Cellular Neuroscience

PMID 30405358, DOI

2017

Myelin dynamics: protecting and shaping neuronal functions

Aiman S. Saab, Klaus‐Armin Nave

Current Opinion in Neurobiology

PMID 29065345, DOI

Monitoring ATP dynamics in electrically active white matter tracts

Andrea Trevisiol, Aiman S. Saab, Ulrike Winkler, Grit Marx, Hiromi Imamura, Wiebke Möbius, Kathrin Kusch, Klaus‐Armin Nave, Johannes Hirrlinger

eLife

PMID 28414271, DOI

2016

Long-term In Vivo Calcium Imaging of Astrocytes Reveals Distinct Cellular Compartment Responses to Sensory Stimulation

Jillian L. Stobart, Kim David Ferrari, Matthew Barrett, Michael Stobart, Zoe J. Looser, Aiman S. Saab, Bruno Weber

Cerebral Cortex

PMID 28968832, DOI

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

Aiman S. Saab, Iva D. Tzvetavona, Andrea Trevisiol, Selva Baltan, Payam Dibaj, Kathrin Kusch, Wiebke Möbius, Bianka Goetze, Hannah M. Jahn, Wenhui Huang, Heinz Steffens, Eike D. Schomburg, Alberto Pérez‐Samartín, Fernando Pérez‐Cerdá, Davood Bakhtiari, Carlos Matute, Siegrid Löwel, Christian Griesinger, Johannes Hirrlinger, Frank Kirchhoff, Klaus‐Armin Nave

Neuron

PMID 27292539, DOI

A mechanism for myelin injury

Aiman S. Saab, Klaus‐Armin Nave

Nature

PMID 26760205, DOI

2015

Design and performance of an ultra-flexible two-photon microscope for in vivo research

Johannes M. Mayrhofer, Florent Haiss, Dominik Haenni, S E Weber, Marc Zuend, Matthew Barrett, Kim David Ferrari, Philipp Maechler, Aiman S. Saab, Jillian L. Stobart, Matthias T. Wyss, Helge C. Johannssen, Harald Osswald, Lucy M. Palmer, Vincent Revol, Claus‐Dieter Schuh, C. Urban, Andrew M. Hall, Matthew E. Larkum, Edith Rutz-Innerhofer, Hanns Ulrich Zeilhofer, Urs Ziegler, Bruno Weber

Biomedical Optics Express

PMID 26600989, DOI

2013

The role of myelin and oligodendrocytes in axonal energy metabolism

Aiman S. Saab, Iva D. Tzvetanova, Klaus‐Armin Nave

Current Opinion in Neurobiology

PMID 24094633, DOI

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

Carsten Frühbeis, Dominik Fröhlich, Wen Ping Kuo, Jesa Amphornrat, Sebastian Thilemann, Aiman S. Saab, Frank Kirchhoff, Wiebke Möbius, Sandra Goebbels, Klaus‐Armin Nave, Anja Schneider, Mikael Simons, Matthias Klugmann, Jacqueline Trotter, Eva‐Maria Krämer‐Albers

PLoS Biology

PMID 23874151, DOI

Genetic Background Affects Human Glial Fibrillary Acidic Protein Promoter Activity

Xianshu Bai, Aiman S. Saab, Wenhui Huang, Isolde K. Hoberg, Frank Kirchhoff, Anja Scheller

PLoS ONE

PMID 23826164, DOI

2012

Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination

Aiman S. Saab, Alexander Neumeyer, Hannah M. Jahn, Alexander Cupido, Antonia A. M. Šimek, Henk‐Jan Boele, Anja Scheller, Karim Le Meur, Magdalena Götz, Hannah Monyer, Rolf Sprengel, María E. Rubio, Joachim W. Deitmer, Chris I. De Zeeuw, Frank Kirchhoff

Science

PMID 22767895, DOI

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Ursula Fünfschilling, Lotti M. Supplie, Don Mahad, Susann Boretius, Aiman S. Saab, Julia M. Edgar, Bastian G. Brinkmann, Celia M. Kassmann, Iva D. Tzvetanova, Wiebke Möbius, Francisca Díaz, Dies Meijer, Ueli Suter, Bernd Hamprecht, Michael W. Sereda, Carlos T. Moraes, Jens Frahm, Sandra Goebbels, Klaus‐Armin Nave

Nature

PMID 22622581, DOI

2010

Why do oligodendrocyte lineage cells express glutamate receptors?

Karolina Kołodziejczyk, Aiman S. Saab, Klaus‐Armin Nave, David Attwell

F1000 Biology Reports

PMID 21173873, DOI

Electron Microscopy of the Mouse Central Nervous System

Wiebke Möbius, Benjamin H. Cooper, Walter A. Kaufmann, Cordelia Imig, Torben Ruhwedel, Nicolas Snaidero, Aiman S. Saab, Frédérique Varoqueaux

Methods in cell biology

PMID 20869535, DOI

2009

Phosphatidylinositol 4,5-Bisphosphate-Dependent Interaction of Myelin Basic Protein with the Plasma Membrane in Oligodendroglial Cells and Its Rapid Perturbation by Elevated Calcium

Schanila Nawaz, Angelika Kippert, Aiman S. Saab, Hauke Werner, Thorsten Lang, Klaus‐Armin Nave, Mikael Simons

Journal of Neuroscience

PMID 19369548, DOI

Neuroglial Pharmacology, Saab Lab

Institute of Pharmacology and Toxicology, University of Zurich.

Contact the lab